Condition: Schizophrenia · Schizoaffective Disorder · Sponsor: Centre for Addiction and Mental Health
Plasma half-life has routinely been used to establish the dosing schedule of antipsychotics; for example, it is recommended that agents with a short plasma half-life be administered multiple times per day. However, to date, several randomized controlled trials (RCTs) have shown no differences in clinical outcomes between once- and twice-daily dosing of various antipsychotics, suggesting that once-daily dosing of antipsychotics is a viable option regardless of plasma half-life. This would apply to clozapine as well; however, there have been no studies comparing once-daily vs. twice-daily dosing regimens of clozapine in terms of efficacy and tolerability. To address this gap in the literature, the investigators shall conduct a pilot, double-blind, RCT to examine efficacy and tolerability following a switch to once-daily dosing regimen of clozapine in patients with schizophrenia receiving clozapine twice a day.
This description comes directly from the study's public registry record.
Gary Remington, MD, PhD · +1-416-535-8501 · Gary.Remington@camh.ca
Carol Borlido, BSc · 416 535-8501 · carol.borlido@camh.ca
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| Centre for Addiction and Mental Health | Toronto, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT02639702