Condition: Prostate Cancer · Prostate Biopsy · Genetic Counselling · Sponsor: Institute of Cancer Research, United Kingdom
Prostate cancer is now the most common cancer in men in the Western world. In the United Kingdom (UK), there were over 52,000 new cases diagnosed in 2016-2018 and a lifetime risk of 1 in 8. Prostate cancer (PrCa) can run in some families and research studies have identified several genetic changes in Caucasian populations that are thought to increase the risk of developing prostate cancer. Other studies have shown that men from certain ethnic groups also have a higher risk of prostate cancer, and this includes men of black African or black African-Caribbean ancestry. This study aims to look at men with a higher risk of prostate cancer based on their ethnicity, family history and/or genetic predisposition to see whether any of these genetic changes are present in their DNA (genetic material) and whether this could be a helpful screening tool in prostate cancer screening programmes. It is thought that many genetic changes are involved in the development of prostate cancer and research is being carried out worldwide to identify these genetic changes. Some of these changes may cause a very slight increase in prostate cancer risk while others may cause a much larger increase in risk of developing prostate cancer. The investigators will invite (i) men of any ethnicity with a family history of prostate cancer; (ii) men of black African or black African-Caribbean ancestry; and (iii) men of any ethnicity with a known genetic predisposition to having prostate cancer (e.g., being known …
This description comes directly from the study's public registry record.
Elizabeth K Bancroft, PhD · 44 207 808 2136 · elizabeth.bancroft@icr.ac.uk
Eva McGrowder, PhD · 44 208 722 4483 · eva.mcgrowder@icr.ac.uk
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| Institute of Cancer Research and Royal Marsden Hospital | Sutton, Surrey, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT02543905