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Study identifier: NCT02491099 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Phase II Evaluation of Afatinib in Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma

Condition: HER2/Neu+ Uterine Serous Carcinoma  ·  Sponsor: Yale University

PhasePhase 2
Planned participants50
Who can joinFemale, 18 Years to 100 Years
Healthy volunteersNo

About this study

Primary Objective: To assess the activity of Afatinib in patients with persistent or recurrent uterine serous carcinoma overexpressing HER2/neu with the frequency of patients who survive progression-free for at least 6 months after initiating therapy. Secondary Objectives: To assess objective response rate and durable disease control rate. To assess overall survival. To assess the safety profile of Afatinib in uterine serous carcinoma patients.

This description comes directly from the study's public registry record.

Talk to the study team

Alessandro D. Santin, M.D.  ·  203-737-4450  ·  alessandro.santin@yale.edu

Lisa Baker, R.N.  ·  203-785-6398  ·  lisa.baker@yale.edu

Always discuss trial participation with your own doctor first.

Locations (3)

University of Arizona Cancer CenterTucson, Arizona, United StatesCompleted
Yale New Haven HospitalNew Haven, Connecticut, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesCompleted

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Source record: clinicaltrials.gov/study/NCT02491099