Condition: Scoliosis · Sponsor: St. Justine's Hospital
Scoliosis is a three-dimensional deformity affecting the orientation and position of the spine. Locally, the shape of the vertebra is also affected. The most common form is adolescent idiopathic scoliosis (AIS) with a prevalence of 1-3% affecting primarily young adolescent females. AIS can either be treated using a brace and in some cases necessitate surgical correction to prevent progressive deformity. Risk factors for progression include female gender, curve magnitude and location, skeletal maturity and growth velocity. However, these risk factors have been shown to be inconsistent in predicting curve progression. Over the past 6 years, the investigators have developed a predictive model of the final Cobb angle in AIS based on 3D spinal parameters. This analysis was based on a prospective cohort of 195 patients that were enrolled upon their initial visit and followed until maturity. This predictive model has a determination coefficient of 0.702. The proposed new study aims at refining and testing the external validity of this model in a larger cohort. The next step towards using the new model in the clinical setting is to redesign the model and to externally validate the model by measuring the agreement between the new method and the traditional Cobb angle at maturity in a larger multicenter study. The objective of this study is to characterize the risk of scoliosis progression based on local three-dimensional vertebral and pelvic measurements present on initial evaluation.…
This description comes directly from the study's public registry record.
Stefan Parent, MD, PhD · stefan.parent@umontreal.ca
Marjolaine Roy-Beaudry · marjolaine.roy-beaudry.hsj@ssss.gouv.qc.ca
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| Rady Children's Hospital | San Diego, California, United States | Recruiting |
| Alfred I. duPont Hospital for Children | Wilmington, Delaware, United States | Not Yet Recruiting |
| Miami Children's Hospital | Miami, Florida, United States | Not Yet Recruiting |
| Mayo Clinic | Minneota, Minnesota, United States | Not Yet Recruiting |
| St Justine's Hospital | Montreal, Quebec, Canada | Recruiting |
| Robert Debré Hospital | Paris, France | Not Yet Recruiting |
| Queen Mary Hospital | Hong Kong, Hong Kong | Recruiting |
| The Meijo Hospital | Nagoya, Japan | Recruiting |
| National University | Singapore, Singapore | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT02434003