Condition: Osteogenesis Imperfecta · Sponsor: Baylor College of Medicine
Osteogenesis Imperfecta (OI) is a rare disorder of increased bone fragility characterized by fractures with minimal or absent trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss. It is seen in both genders and all races. The clinical features of OI represent a continuum varying from perinatal lethality to individuals with severe skeletal deformities, mobility impairments, and very short stature to nearly asymptomatic individuals with a mild predisposition to fractures, normal stature, and normal lifespan. Fractures can occur in any bone, but are most common in the extremities. These disorders can be devastating and progressive and result in deformity, chronic pain, impaired function and loss of quality of life. The overall goal of this study is to answer specific question about the natural history of brittle bone diseases as defined by molecular etiology and to develop the foundation for prospective clinical studies.
This description comes directly from the study's public registry record.
Dianne Nguyen · 713.798.6694 · diannen@bcm.edu
Always discuss trial participation with your own doctor first.
| Phoenix Children's Hospital | Phoenix, Arizona, United States | Recruiting |
| University of California Los Angeles | Los Angeles, California, United States | Recruiting |
| AI Dupont Hospital for Children | Wilmington, Delaware, United States | Recruiting |
| Children's National Medical Center | Washington D.C., District of Columbia, United States | Recruiting |
| University of South Florida | Tampa, Florida, United States | Recruiting |
| Kennedy Krieger Institute / Hugo W. Moser Research Institute | Baltimore, Maryland, United States | Recruiting |
| University of Nebraska Medical Center | Omaha, Nebraska, United States | Recruiting |
| Hospital for Special Surgery | New York, New York, United States | Recruiting |
| Oregon Health and Science University | Portland, Oregon, United States | Recruiting |
| Baylor College of Medicine | Houston, Texas, United States | Recruiting |
| Shriners Hospital for Children, Chicago / Marquette University | Milwaukee, Wisconsin, United States | Recruiting |
| Shriners Hospital for Children | Montreal, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT02432625