Condition: Pregnancy · IUGR · Preeclampsia · Sponsor: University of Colorado, Denver
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.
This description comes directly from the study's public registry record.
Lorna Moore, PhD · 303-724-7474 · lorna.moore@ucdenver.edu
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| University of Colorado Denver Anschutz Medical Campus | Aurora, Colorado, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT02391519