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Study identifier: NCT02354014 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pharmacokinetic Study to Evaluate Anti-mycobacterial Activity of TMC207 in Combination With Background Regimen (BR) of Multidrug Resistant Tuberculosis (MDR-TB) Medications for Treatment of Children/Adolescents With Pulmonary MDR-TB

Condition: Tuberculosis, Multidrug-Resistant  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 2
Planned participants60
Who can joinAll sexes, 0 Months to 18 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (explores what the body does to the drug), and anti-mycobacterial activity of bedaquiline (TMC207) in children and adolescents (0 months to less than \[\<\] 18 years of age) diagnosed with confirmed or probable pulmonary multidrug resistant tuberculosis (MDR-TB), in combination With a Background Regimen (BR) of MDR-TB Medications.

This description comes directly from the study's public registry record.

Talk to the study team

Study Contact  ·  Participate-In-This-Study1@its.jnj.com

Always discuss trial participation with your own doctor first.

Locations (11)

Hospital Geral da Polana CaniçoMaputo, MozambiqueCompleted
De La Salle Health Sciences Institute- DLSUMCDasmariñas, PhilippinesRecruiting
Lung Center Of The PhilippinesQuezon City, PhilippinesCompleted
Silang Specialists Medical CenterSan Vincent Silang, PhilippinesRecruiting
First Moscow State Medical University n.a. I.M. SechenovMoscow, RussiaCompleted
THINK: Tuberculosis & HIV Investigative NetworkDurban, South AfricaCompleted
Sizwe Tropical Diseases HospitalJohannesburg, South AfricaRecruiting
Wits Health ConsortiumPort Elizabeth, South AfricaRecruiting
Desmond Tutu TB CentreStellenboch, South AfricaRecruiting
Makerere University Lung InstituteKampala, UgandaTerminated
State Institute Of Phthisiology And Pulmonology N.A. F.G. Yanovskiy Of Ams UkraineKiev, UkraineCompleted

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Source record: clinicaltrials.gov/study/NCT02354014