Condition: Familial Hypercholesterolemia · Sponsor: Russian Cardiology Research and Production Center
True prevalence of FH in the Russian Federation is unknown which leads to low percentage of diagnosed and treated cases. Research is needed to determine the prevalence of FH, specific diagnostic algorithms and optimal treatment strategies. The main aim of the present study is to evaluate the extent to which FH is underdiagnosed and undertreated in the Russian Federation for reduction of cardiovascular risk related to atherosclerosis in the country. As a first step, total cholesterol (TC) and low-density lipoprotein (LDL-C) levels will be determined in a random sample from Moscow population (n=18000). It is expected that TC ≥ 7.5 mmol/L will be detected in 10% of cohort. During 2014, approximately 500 patients will pass through non-invasive clinical examination at the Russian Cardiology Research and Production Center, including patient demographics, past medical history, family history of hypercholesterolemia, physical findings, current lipid-lowering therapies, blood tests, genetic analysis, echocardiography, carotid duplex ultrasound and exercise SPECT imaging in selected cases. On the basis of the Moscow Program four major Federal Medical Centers will be involved, and FH Registry will be created as a national, multi-center initiative to screen FH patients, control their diagnosis and management, and track clinical-reported outcomes over time. Establishment of National Guidelines for the diagnosis and treatment of FH on the basis of these data and implementation those into…
This description comes directly from the study's public registry record.
Marat Ezhov, MD, PhD · +79104137499 · Marat_Ezhov@mail.ru
Igor Sergienko, MD, DMSc · +79031492253 · igorcardio@mail.ru
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| Chelyabinsk State Medical Academy | Chelyabinsk, Russia | Not Yet Recruiting |
| EI Chazov National Medical Research Center of Cardiology | Moscow, Russia | Recruiting |
| Novosibirsk Research Institute of Internal Medicine, Institute of Internal Medicine Siberian Branch of the Russian Academy of Medical Sciences | Novosibirsk, Russia | Not Yet Recruiting |
| Saint-Petersburg State University and North-West State Medical University n.a. I.I.Mechnikov | Saint Petersburg, Russia | Not Yet Recruiting |
| Samara State Medical University | Samara, Russia | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT02208869