Condition: Squamous Cell Carcinoma · Sponsor: Christopher Wilke
The goal of this clinical research study is to learn which chemotherapy combination may be more effective in treating locally advanced head and neck squamous cell carcinoma (HNSCC). The side effects of these combinations will also be studied. This study treatment consists of intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy. For study chemotherapy, patients will be randomized between cisplatin or the combination of docetaxel and cetuximab. Subjects will be stratified depending on HPV status and the presence of ERCC-1 \[4F9\] in the tumor prior to randomization. The study will evaluate cisplatin vs. docetaxel-cetuximab in the overall population, and test which radiation and chemotherapy combination works best in relationship to how much ERCC-1 \[4F9\] is expressed in a tumor.
This description comes directly from the study's public registry record.
Samantha Demko, RN · 412-647-9015 · albesl@upmc.edu
Brieana Marino, MS · 412-647-8258 · rowlesbm@upmc.edu
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| UPMC Hillman Cancer Center - Radiation Oncology | Pittsburgh, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT02128906