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Study identifier: NCT02102022 Synced from ClinicalTrials.gov · July 28, 2026
● Terminated

Ph 1-2 Study ADI-PEG 20 Plus FOLFOX in Subjects With Advanced GI Malignancies Focusing on Hepatocellular Carcinoma

Condition: Advanced Gastrointestinal (GI) Malignancies · Hepatocellular Carcinoma · Gastric Cancer  ·  Sponsor: Polaris Group

PhasePhase 1/Phase 2
Planned participants140
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Phase 1: Assessment of safety and tolerability of ADI-PEG 20 in combination with folinic acid (leucovorin), fluorouracil and oxaliplatin (FOLFOX) in advanced GI malignancies. Phase 2: Assessment of the objective response rate (ORR), measured by RECIST 1.1 criteria as assessed by blinded independent central review (BICR).

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (35)

California Pacific Medical CenterSan Francisco, California, United States
Emory UniversityAtlanta, Georgia, United States
The University of Chicago Medical CenterChicago, Illinois, United States
The University of Kansas Cancer CenterWestwood, Kansas, United States
Masonic Cancer CenterMinneapolis, Minnesota, United States
Washington UniversitySt Louis, Missouri, United States
Memorial Sloan-Kettering Cancer CenterNew York, New York, United States
Oregon Health and Science UniversityPortland, Oregon, United States
UPMC Hillman Cancer CenterPittsburgh, Pennsylvania, United States
University of WashingtonSeattle, Washington, United States
The Chinese People's Liberation Army 81 HospitalNanjing, Jiangsu, China
West China Hospital, Sichuan UniversityChengdu, Sichuan, China

+ 23 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT02102022