Condition: Cystic Fibrosis · Sponsor: Children's Hospital of Philadelphia
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.
This description comes directly from the study's public registry record.
Rachel Walega · 267-586-5969 · walegar1@chop.edu
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| The Children's Hopsital of Philadelphia | Philadelphia, Pennsylvania, United States | Recruiting |
| The University of Pennsylvania | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT01852448