Condition: Endometriosis · Sponsor: Turku University Hospital
Endometriosis is a chronic disease characterized by the presence of functional endometrial glands and stroma in ectopic locations outside the uterine cavity. The ectopic endometrial tissue responds to estradiol and other hormones similarly to the normal endometrium. Endometriosis is one of the most common benign gynecological conditions, as many as 5-10% of women in the reproductive age may be affected. In addition to pain which may be severe, subfertility is one of the typical problems associated with endometriosis and may be present in up to 40% of those affected. There is lack of a clear correlation between severity of pain and degree of compromised fertility. Different modes of treatment exist. Hormonal treatments are based on the suppression of estrogenic action on endometriosis as well as the endometrium. Unfortunately, discontinuation of the hormonal treatment typically results in a rapid recurrence of the disease. Surgery may alleviate the symptom for different lengths of time, however, curative treatment frequently involves hysterectomy with bilateral oophorectomy. In order to escape this radical treatment, new targeted therapy in the form of novel pharmacological agents would be of crucial importance. Presently, endometriosis can be reliably diagnosed only by laparoscopy. Since this is an invasive surgical procedure, new diagnostic tools would be warmly welcomed. Furthermore, as the progression of the disease is presently impossible to predict, new markers for the "…
This description comes directly from the study's public registry record.
Antti H Perheentupa, MD PhD · +358-2-3130000 · antti.perheentupa@utu.fi
Kaisa Huhtinen, PhD · +358-2-333 7376 · kaisa.huhtinen@utu.fi
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| Dept of Obstetrics and Gynecology, Helsinki University Hospital | Helsinki, Finland | Completed |
| Dept of Obstetrics and Gynecology, North Carelia Central Hospital | Joensuu, Finland | Completed |
| Dept of Obstetrics and Gynecology, Päijät-Häme Central Hospital | Lahti, Finland | Completed |
| Dept of Obstetrics and Gynecology, Turku University Central Hospital | Turku, Finland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT01301885