Condition: Myositis · Dermatomyositis · Polymyositis · Sponsor: National Institute of Environmental Health Sciences (NIEHS)
Background: * Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors. Some researchers believe that people who are susceptible to autoimmune disorders develop them when the body reacts to environmental or other factors by creating white blood cells that attack the body s own tissues, which then progresses to autoimmune diseases. These immune-triggered disorders can overlap with one another to some extent, but most autoimmune diseases have certain distinct triggers. * The autoimmune disorder myositis weakens the muscles and may cause other health problems. Environmental exposures associated with myositis include ultraviolet radiation, stressful life events and muscle overexertion, collagen implants, infections such as retroviruses and streptococci bacteria, and certain drugs and chemicals. Some individuals with myositis also produce proteins in the blood called autoantibodies that react with certain parts of the person s own cells, called synthetases, which are involved in making new proteins. A syndrome called the anti-synthetase syndrome, which includes myositis and lung disease, is associated with having the anti-synthetase autoantibodies. Researchers are interested in studying differences in environmental exposures in individuals with myositis. This study is being conducted to determine if persons with the anti-synthetase syndrome have had different environmental exposures before disease onset compar…
This description comes directly from the study's public registry record.
Adam I Schiffenbauer, M.D. · (301) 451-6270 · schiffenbauera2@mail.nih.gov
Always discuss trial participation with your own doctor first.
| University of Miami Hospital | Miami, Florida, United States | Withdrawn |
| Johns Hopkins University | Baltimore, Maryland, United States | Completed |
| National Institutes of Health Clinical Center | Bethesda, Maryland, United States | Recruiting |
| Mid-Atlantic Kaiser Permanente | Rockville, Maryland, United States | Completed |
| Brigham and Women's Hospital | Boston, Massachusetts, United States | Completed |
| Mayo Clinic, Rochester | Rochester, Minnesota, United States | Completed |
| NIEHS Clinical Research Unit (CRU) | Research Triangle Park, North Carolina, United States | Recruiting |
| University of Pittsburgh | Pittsburgh, Pennsylvania, United States | Completed |
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Source record: clinicaltrials.gov/study/NCT01276470