Condition: Heart Failure, Congestive · Death, Sudden, Cardiac · Arrhythmia · Sponsor: Johns Hopkins University
The overall hypothesis of this study is that subtle interactions between structural (substrate) and functional (trigger) abnormalities of the heart, some of which are genetically-determined, can be used to identify patients at high risk of sudden cardiac death (SCD). Such information may be used to better define patients most likely to benefit from replacement of an internal defibrillator (ICD). The prospective, observational study to enroll, categorize and follow patients who receive an ICD pulse generator replacement for primary prevention of SCD (PROSe-ICD) was established to : 1. to gain a better understanding of the biological mechanisms that predispose to SCD 2. to develop readily determined clinical, electrocardiographic, genetic and blood protein markers identify patients with an increased risk of dying suddenly
This description comes directly from the study's public registry record.
Katherine Wu, MD · 410-502-7283 · kwu@jhmi.edu
Always discuss trial participation with your own doctor first.
| Washington Hospital Center | Washington D.C., District of Columbia, United States | Recruiting |
| University of Maryland Medical Center | Baltimore, Maryland, United States | Recruiting |
| Johns Hopkins University School of Medicine | Baltimore, Maryland, United States | Recruiting |
| Virginia Commonwealth University School of Medicine | Richmond, Virginia, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT00733590