Condition: Malignant Pleural Mesotheliomas NOS · Esophageal Cancers NOS · Lung Cancer NOS · Sponsor: National Cancer Institute (NCI)
Background: * Chromatin is is the structural building block of a chromosome. It is found inside the nucleus of the cell and consists of a complex of DNA and protein. * Cancers of the lung, pleura (lung lining) and esophagus show profound changes in chromatin structure that may affect the course of disease in participants. * A better understanding of these diseases and the genetic changes associated with them may be helpful in developing new treatments for them. Objectives: * To evaluate people with cancer of the lung, pleura or esophagus for participation in NCI clinical trials. * To obtain biopsies (small pieces of tissue) from tumor, normal tissue and blood samples to learn more about the cellular changes in blood and tissue in tumors of the lung, esophagus and pleura and surrounding structures in the chest. Eligibility: Participants 2 years of age and older with cancer of the lung, esophagus, pleura, mediastinum or chest wall, or cancers of other origin that have invaded the lung. Note: Patients \>= 2 years of age and under 18 years of age may only participate in research sample collection. Design: * Up to 1310 participants may be included in this study. * Participants undergo standard tests for evaluating the stage of their disease and for determining eligibility for an NCI investigational treatment study. * All participants undergo bronchoscopy and bronchoalveolar lavage ("washing" with salt water) to assess their tumor and collect a sample of normal tissue. Partic…
This description comes directly from the study's public registry record.
Rebecca B Alexander · (240) 781-4037 · rebecca.alexander@nih.gov
David S Schrump, M.D. · (240) 760-6239 · david_schrump@nih.gov
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| National Institutes of Health Clinical Center | Bethesda, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT00242723